Improved Bioavailability of Poorly Soluble Drugs through Gastrointestinal Muco-Adhesion of Lipid Nanoparticles

Improved Bioavailability of Poorly Soluble Drugs through Gastrointestinal Muco-Adhesion of Lipid Nanoparticles

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Gastrointestinal absorption remains indispensable in the systemic delivery of most drugs, even though it presents several challenges that, paradoxically, may also provide opportunities that can be exploited to achieve maximal bioavailability.Drug delivery systems made from nanoparticle carriers and especially, lipid carriers, iphone 13 pro max price florida have the potential to traverse gastrointestinal barriers and deploy in the lymphatic pathway, which aptly, is free from first pass via the liver.Several poorly soluble drugs have presented improved systemic bioavailability when couriered in lipid nanoparticle carriers.In this review, we propose an additional frontier to enhancing the bioavailability of poorly soluble g5210t-p90 drugs when encapsulated in lipid nano-carriers by imparting muco-adhesion to the particles through application of appropriate polymeric coating to the lipid copyright.

The combined effect of gastrointestinal muco-adhesion followed by lymphatic absorption is a promising approach to improving systemic bioavailability of poorly soluble drugs following oral administration.Evidence to the potential of this approach is backed-up by recent studies within the review.